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From: Jacob
Date: 10/4/2002
Time: 7:28:03 AM
Remote Name: 24.159.254.74
http://www.pharmcast.com/Patents/082499OG/5942245_sod090299.htm
A particular object of the present invention is the use of the synergistic effect of a mixture of hyaluronic acid and SOD. Hyaluronic acid has also recently become known to those skilled in the art for its "free radical acceptor properties", and its use in wound treatment has repeatedly been described (Amgen, NO 9214480, 1992). The use of hyaluronic acid together with Colony Stimulating Factor (CSF) or Platelet Derived Growth Factor (PDGF) for accelerating wound healing has also been described in the literature (Zymogenetics, U.S. Pat. No. 5,128,321, 1992), and hyaluronic acid has also been described as an additive in cosmetics and pharmaceutical preparations (Shiseido, WO 9104279, 1991).
On the other hand--surprisingly--a combination of hyaluronic acid and SOD, in particular a mixture of hyaluronic acid and liposomally incorporated SOD, has not been described to date. To what extent this represents or represented a prejudice on the part of those skilled in the art cannot be adequately assessed at the present time. In any case, it was surprisingly found, in the course of the experiments which have finally led to the present invention, that hyaluronic acid supports and reinforces the effect of SOD, also of liposomally incorporated SOD, in an almost ideal manner
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