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Topic 604: Topical forum # 20 - FNS, Biolyn, SOD, Fluridil, Peptides et al 

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Re: latanoprost revisited

From: frizz to sdm
Date: 10/6/2002
Time: 7:33:05 PM
Remote Name: 65.26.86.226

Comments

hey stephen, youre the adventurous type, why dont you buy some .PSI (proteasom inhibitor) @ peptides international. here is a recent post from sqb:

Another good one using Proteasom inhibitors...

http://appft1.uspto.gov/netacgi/nph-Parser?Sect1=PTO2&Sect2=HITOFF&p=1&u=/netahtml/PTO/search-bool.html&r=3&f=G&l=50&co1=AND&d=PG01&s1=mundy&s2=hair&OS=mundy+AND+hair&RS=mundy+AND+hair

this one works by inhibiting the activity of NF-.kappa.B or inhibit the activity of the proteasome Note* all of these proteasom inhibitors are available like the PSI N-carbobenzoyl-Ile-Glu-(OtBu)-Ala-Leu-CHO used in the study... $84 5mg "[0062] PSI was prepared as a topical formulation, where the vehicle was 50% propylene glycol, 30% ethanol, 20% deionized water, at 0.1% concentration of PSI. The solution was applied 3 times a day for 5 days. The mice in a treated group were observed as compared to controls similarly treated with vehicle alone. The results at day 16 showed stimulation of hair growth relative to the controls. "

"[0063] In addition to stimulating hair growth, PSI was able to thicken both the hair and the hair shaft. PSI increases hair count when the follicle area is greater than 0.01 mm.sup.2. When the protocol above was repeated using a 0.5% solution of PSI in groups containing 5 mice each, the number of hairs per 0.8 mm.sup.2 was 60 in the treated mice versus about 10 in the control group. The percentage of follicle area in a region of about 0.8 mm.sup.2 was about 30% as an average in the treated group as compared to 15% as an average in the control group. "

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