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Topic 610: WSMR HairSwitch, Flex S1, 2, peptides, Biolyn, FNS, & Other Topical Treatments - forum 21

Re: My Personal Topical Experiment.

From: S Foote to `E'
Date: 10/25/2002
Time: 7:12:58 AM
Remote Name: 195.93.49.8

Comments

Thanks for your comments E.

The theory developed from considering basic hair follicle `Physics', and why they evolved in the first place!

The hair cycle is the regular expansion and shrinkage of the follicle within the dermis. The longer the anagen enlargement period, the larger the follicle, the more hair produced. So what is known about factors in biology that could influence follicle enlargement?

There is a basic control system in multi cellular biology that dictates the ultimate size of any developing organ, including hair follicles! This is contact inhibition. Any search for contact inhibition will bring up many references to this. Basicaly this means that any enlarging organ can only be as large as space permits. This ensures that structures within the body don't interfere with each other. If pressure is put on an enlarging structure by the tissue around it, contact inhibition `switches off' this enlargement.

Contact inhibition makes a link between enlarging anagen hair follicles, and the fluid pressure in the tissue around them. As the follicles start to enlarge they have to `push' the surrounding tissue out of the way. The higher the fluid pressure in this tissue, the harder it is for the enlarging follicle to move it. Therefore, the higher the pressure in surrounding tissue,the earlier anagen enlargement is switched off by contact inhibition, the smaller the follicle, and less hair production. The lower the fluid pressure, the longer the anagen enlargement period, the larger the follicle, and hair growth is increased.

In my opinion, hair follicles evolved to `adjust' hair production according to the fluid pressure in the surrounding tissue.

The primary temperatue control in mammals is a highly adjustable blood supply to the dermal tissue, (The tissue around hair follicles). In a cold environment blood flow to the dermis is restricted to conserve body heat. This reduces the pressure in the dermis, allowing the developement of larger follicles, and increased hair growth, which is just what happens in hairy mammals in cold environments. They develope a winter coat!! As temperatures increase blood flow increases to the dermis to disipate heat, and the pressure around follicles increases creating a `moult' and reduced hair growth as described in the "Hydraulic Dermal Model" section of my paper.

This is a simple integrated temperature control in evolving mammals. What this means for us is that ANY changes in fluid pressure around hair follicles for ANY reason, will effect hair growth!!

If you look at how DHT effects hair growth and where most DHT is produced (The periferal tissues), the suggestion is that DHT significantly increases lymphatic drainage as i argue in my paper.

You have to remember that DHT INCREASES hair growth over the larger part of the body. A look at the layout of the lymphatic system of the head suggests a reason why this could increase fluid pressure in the scalp and lead to MPB in some individuals. http://137.222.110.150/calnet/DeepNeck/page3.htm#section3 Looking at this you can see that the MPB area lies at the extreme ends of the lymphatic layout. If as proposed DHT increases lymphatic `pumping' this could create a back pressure effect at the ends of the vessels because of the one way valves in the lymph vessels. The human head has the most complex `plumbing' system in nature. Depending on an individuals fluid `feed' to the scalp, the back pressure effect of DHT created in the face and neck could lead to edema of the scalp, and MPB according to the theory. This pressure in the balding scalp would also restrict the free circulation of blood through the scalp, adding to the problem of fluid retention. reduced circulation is recognised in MPB.

This is why i decided to try to reduce levels of DHT in the face and neck that would cause the back pressure. As i said, according to the theory this should be the most effective way to reverse the MPB proccess.

The predicted effect of DHT on lymphatic drainage has important implications for the further understanding of some serious female related diseases. This aspect has been taken seriously enough that a reputable research establishment is currently testing this.

S Foote.